Metastasis is the primary cause of mortality associated with cancer and tumor genomic
heterogeneity is a likely source for the cells that support cancer progression resistance to
therapy and disease relapse. This book connects cancer metastasis with genomic instability in
a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these
cellular and tissue phenotypes. Section 2 discusses in silico in vitro and in vivo models
used for the experimental study of these processes. Section 3 reviews emerging themes (ex.
microenvironment mechanotransduction and immunomodulation) and Section 4 highlights new
therapeutic approaches to overcome the unique challenges presented by the heterogeneous and
metastatic tumor. This book is intended for undergraduates and postgraduates with an interest
in the areas of medicine oncology and cancer biology as well as for the content expert
searching for thorough reviews of current knowledge in these areas.
