PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in
cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose
polymerase) and its role in DNA repair. In addition a description of discovery of the PARP
family and other DNA maintenance-associated PARPs will also be discussed. The volume also
features a section on accessible chemistry behind the development of inhibitors. PARP
inhibitors are a group of pharmacological inhibitors that are a particularly good target for
cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic
resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous
amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited
by PARPi. The ¿synthetic lethality¿ of PARPi is an exciting concept for cancer therapy and has
led to a heightened activity in this area.
