EAN: 9783319445328

SYSTEMS PHARMACOLOGY AND PHARMACODYNAMICS GEBUNDEN

While systems biology and pharmacodynamics have evolved in parallel  there are significant
interrelationships that can enhance drug discovery and enable optimized therapy for each
patient. Systems pharmacology is the relatively new discipline that is the interface between
these two methods. This book is the first to cover the expertise from systems biology and
pharmacodynamics researchers  describing how systems pharmacology may be developed and refined
further to show practical applications in drug development. There is a growing awareness that
pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient
efficacy or toxicity found in proof-of-concept and or Phase II studies. Systems Pharmacology
and Pharmacodynamics discusses the framework for integrating information obtained from
understanding physiological pathological pathways (normal body function system vs. perturbed
system due to disease) and pharmacological targets in order to predict clinical efficacy and
adverse events through iterations between mathematical modeling and experimentation.

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