EAN: 9783319781532

INNOVATIONS FOR NEXT-GENERATION ANTIBODY-DRUG C...

Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical
programs have yielded only a few regulatory approvals  but a wave of technological innovation
now empowers us to overcome past technical challenges. This volume focuses on the next
generation of ADCs and the innovations that will enable them. The book inspires the future by
integrating the field's history with novel strategies and cutting-edge technologies. While the
book primarily addresses ADCs for solid tumors  the last chapter explores the emerging interest
in using ADCs to treat other diseases.The therapeutic rationale of ADCs is strong: to direct
small molecules to the desired site of action (and away from normal tissues) by conjugation to
antibodies or other targeting moieties. However  the combination of small and large molecules
imposes deep complexity to lead optimization  pharmacokinetics  toxicology  analytics and
manufacturing. The field has made significant advances in all of these areas by improving
target selection  ADC design  manufacturing methods and clinical strategies. These innovations
will inspire and educate scientists who are designing next-generation ADCs with the potential
to transform the lives of patients.

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