EAN: 9783527340408

POLYMORPHISM IN THE PHARMACEUTICAL INDUSTRY GEB...

Polymorphism in the Pharmaceutical Industry - Solid Form and Drug Development highlights the
relevance of polymorphism in modern pharmaceutical chemistry  with a focus on quality by design
(QbD) concepts. It covers all important issues by way of case studies  ranging from properties
and crystallization  via thermodynamics  analytics and theoretical modelling right up to patent
issues. As such  the book underscores the importance of solid-state chemistry within chemical
and pharmaceutical development. It emphasizes why solid-state issues are important  the
approaches needed to avoid problems and the opportunities offered by solid-state properties.
The authors include true polymorphs as well as solvates and hydrates  while providing
information on physicochemical properties  crystallization thermodynamics  quantum-mechanical
modelling  and up-scaling. Important analytical tools to characterize solid-state forms and to
quantify mixtures are summarized  and case studies on solid-state development processes in
industry are also provided. Written by acknowledged experts in the field  this is a
high-quality reference for researchers  project managers and quality assurance managers in
pharmaceutical  agrochemical and fine chemical companies as well as for academics and newcomers
to organic solid-state chemistry.

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