EAN: 9780123978844

TRANSLATIONAL SYSTEMS BIOLOGY - YORAM VODOVOTZ ...

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to
market? Are we getting our money's worth in spending for basic biomedical research? In
Translational Systems Biology  Drs. Yoram Vodovotz and Gary An address these questions by
providing a foundational description the barriers facing biomedical research today and the
immediate future  and how these barriers could be overcome through the adoption of a robust and
scalable approach that will form the underpinning of biomedical research for the future. By
using a combination of essays providing the intellectual basis of the Translational Dilemma and
reports of examples in the study of inflammation  the content of Translational Systems Biology
will remain relevant as technology and knowledge advances bring broad translational
applicability to other diseases. Translational systems biology is an integrated  multi-scale 
evidence-based approach that combines laboratory  clinical and computational methods with an
explicit goal of developing effective means of control of biological processes for improving
human health and rapid clinical application. This comprehensive approach to date has been
utilized for in silico studies of sepsis  trauma  hemorrhage  and traumatic brain injury  acute
liver failure  wound healing  and inflammation.

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