Protein-Protein Docking

This volume covers a wide array of topics on protein-protein docking ranging from the fundamentals of the method and its recent developments to docking tools and examples of protein-protein docking applications. The chapters in this book are organized into four parts. Part One looks at the fundamentals of protein-protein docking such as rigid and flexible docking, and sampling and scoring in protein-protein docking. Part Two focuses on the latest advancements made in the field such as how the protein backbone flexibility is treated. Part Three explores practical applications of protein-protein docking tools and databases, with emphasis on software for predicting binding free energy of protein-protein complexes and their mutants. Part Four talks about protein-protein docking approaches to different systems, and their challenges and strategies of molecular docking of intrinsically disordered proteins. Written in the highly successful Methods in Molecular Biology series format,...