EAN: 9781493967414

EPIGENETICS AND GENE EXPRESSION IN CANCER INFLA...

This practical collection examines methodologies originating from the benefits of genome-wide
approaches to studying epigenetics  which has opened the emerging field of epigenomics.
Focusing on the areas of cancer  inflammatory and autoimmune disorders  chapters discuss three
main components of the epigenome and their role in the regulation of gene expression and
present a detailed method section specific to studying each component  including data analyses
troubleshooting  and feasibility in different experimental settings. The main topics are
high-throughput and targeted methods for DNA methylation analysis  nucleosome position mapping
studying epigenetic effects of gut microbiota  optical imaging for detection of epigenetic
aberrations in living cells  methods for microRNA  and histone code profiling. Written for the
Methods in Pharmacology and Toxicology series  the book includes the kind of detail and
implementation advice to encourage success in the lab. Authoritative and easily applicable 
Epigenetics and Gene Expression in Cancer  Inflammatory and Immune Diseases aims to provide
pharmacologists  molecular biologists  bioinformaticians  and toxicologists with a vital
background on epigenetics and state-of-the-art techniques in epigenomics.

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