Top Experts Share Clinical Insights on Biological Interventions for Spine-Related Disease
Although there have been significant advancements in minimally invasive spinal surgery
techniques in the last few decades optimal outcomes for chronic low back pain remain elusive.
A number of promising clinical trials have been conducted using tissue engineering and
biological interventions for disc degeneration. Written by renowned innovators this is the
first book that covers implementation of these groundbreaking approaches for disc disease. The
text begins with key fundamentals including anatomy and physiology pathophysiology imaging
and biomechanics to delineate healthy versus diseased spine. Subsequent sections discuss
treatment strategies research findings and future developments. Throughout each chapter
renowned spine surgeons and scientists share clinical pearls gleaned from hands-on experience.
Key Highlights - The current state of the art in biological and tissue engineering procedures
for spinal disorders - Treatment methodologies including nucleus replacement and repair
annulus fibrosus repair total disc transplantation and mechanical total disc replacement -
Innovative treatment strategies for disc regeneration such as genes and proteins - Growth
factors including platelet-rich plasma (PRP) which has shown promise for the stimulation and
acceleration of bone and soft tissue healing - Cell-based therapy for spinal disc regeneration
and repair including the use of stem cells and chondrocytes - In-depth discussion of research
including animal versus human model in-vitro and a summary of biologic clinical trials This
is a must-have resource for trainee and practicing orthopaedic surgeons and neurosurgeons who
treat patients for spine-related conditions. It is essential reading for all clinicians who
have an interest in cutting-edge tissue engineering and biological treatment interventions.
