EAN: 9783030142643

DIRECT MECHANISMS IN CHOLESTEROL MODULATION OF ...

In this book  renowned scientists describe how cholesterol interacts with various proteins.
Recent progress made in the high-resolution visualization of cholesterol-protein interactions
using crystallography and cryogenic electron microscopy has substantially advanced the
knowledge of critical features. These features enable specific recognition of the cholesterol
molecule by proteins  a process that was built on earlier studies using binding assays 
computational modeling and site-directed mutagenesis. Direct Mechanisms in Cholesterol
Modulation of Protein Function offers comprehensive insights into the current understanding of
cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are
organized into two distinct parts. In the first part  the chapters introduce the reader to the
general characteristics of cholesterol binding sites in proteins. This part starts with a tour
into common cholesterol recognition motifs  followed by an overview of the major classes of
steroid-binding proteins. It then continues with two chapters that present a comprehensive
analysis of molecular and structural characteristics of cholesterol binding sites in
transmembrane and soluble protein domains. In the second part of the book  examples of
cholesterol binding sites and consequences of specific cholesterol recognition for protein
function are presented for G protein-coupled receptors  ion channels and
cholesterol-transporting proteins.The book is valuable for undergraduate and graduate students
in biochemistry and nutrition  as well as basic science and medical researchers with a keen
interest in the biophysical properties of cholesterol and physiological consequences of
cholesterol presence in biological systems.

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