EAN: 9783319645421

CIRCADIAN RHYTHMS AND THEIR IMPACT ON AGING GEB...

Biological rhythms time the ebb and flow of virtually every physiological process  and their
mutual coordination guarantees the integrity of the organism over space and time. Aging leads
to the disintegration of this coordination  as well as to changes in the amplitude and or
frequency of the underlying rhythms. The results of this are accelerated loss of health during
aging  and in experimental model systems curtailed lifespan occurs. This book will examine the
machinery that constitutes circadian systems and how they impact physiologic processes. It will
also discuss how disturbances of circadian rhythms can lead to complex diseases associated with
aging. Much of this treatment will focus on metabolism and genome stability. Importantly  the
chapters in this book will encompass work in several different models  in addition to human.
The book will conclude with a discussion of modeling approaches to biologic cycles and
chronotherapy  for future research and translation.

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