EAN: 9783319720401

CELLULAR AND MOLECULAR TOXICOLOGY OF NANOPARTIC...

This edited book is a compilation of findings on the molecular and cellular toxicity of
nanoparticles (NPs) in animal cell  human cells  invertebrates. The varied selection of test
models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs
with cells and its organelles can induce toxicological consequences  including transcriptional
and translational alterations  DNA damage  cytotoxicity  oxidative stress  mitochondrial
dysfunction and cell death. NPs can get internalized in cells through phagocytosis 
macropinocytosis  receptor-mediated endocytosis and passive penetration  which can affect
varied cell types. Readers will be benefited with the compilations on basic and molecular facet
of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art
methodologies. The application of toxicogenomic approaches  which is already established in
nanotoxicology  has been given special consideration to unravel the toxicodynamics of
nanomaterials. Among these approaches  the high-throughput RNA sequencing (RNA-Seq)  which is
able to build a complete map of transcriptome across different cell types and perturbations
upon NPs exposure has been included. The readers are also introduced to the less studied topic
on the adsorption of biomolecules (mainly proteins) on the NPs surface  constituting the
so-called biomolecular corona. The book has been designed for scientists engaged in NPs
toxicity research. Nonetheless  it should be of interest to a variety of scientific disciplines
including marine biology  environmental pollution  genetics  pharmacology  medicine  drug and
food material sciences  consumer products. Also  the compilations will be of interest to the
environmental watchdogs  federal regulators  risk assessors and the policy makers.

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