EAN: 9781627037419

OPTIMIZATION IN DRUG DISCOVERY GEBUNDEN

Thoroughly revised and updated  Optimization in Drug Discovery: In Vitro Methods  Second
Edition presents a wide spectrum of in vitro assays including formulation  plasma binding 
absorption and permeability  cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT)
metabolism  CYP inhibition and induction  drug transporters  drug-drug interactions via
assessment of reactive metabolites  genotoxicity  and chemical and photo-mutagenicity assays.
Written for the Methods in Pharmacology and Toxicology series  chapters include introductions
to their respective topics  lists of the necessary materials and reagents  step-by-step 
readily reproducible protocols  and tips on troubleshooting and avoiding known pitfalls. Expert
authors have developed and utilized these in vitro assays to achieve drug-like characteristics
in addition to efficacy properties and good safety profiles of drug candidates.Comprehensive
and up-to-date  Optimization in Drug Discovery: In Vitro Methods  Second Edition aims to guide
researchers down the difficult path to successful drug discovery and development.

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