EAN: 9783110627763

REGULATORY GENES OF ADPA SUBFAMILY IN STREPTOMY...

AdpA is a regulatory protein of the AraC XylS type which was first identified in 1993 as an
activator of streptomycin production by Streptomyces griseus. Today streptomycete genomes are
known to invariably harbor gene adpA  which is important for processes as diverse as
replication and transcriptional control of genes for morphogenesis  antibiotic biosynthesis 
and polymer decomposition to name just a few. Extreme pleiotropicity of adpA gene and its
functional location at the nexus of morphological and physiological differentiation in
Streptomyces fueled numerous investigations of this fascinating group of regulators  in a broad
set of species. This monograph is an attempt to put together all existing information about
functions of AdpA proteins in the context of biological processes it orchestrates. Special
attention is paid to the description of suggested and experimentally proven cases of AdpA
involvement in regulation of antibiotic production. This aspect of AdpA biology might be of
great interest for current efforts to discover novel antibiotics  which are desperately needed
to counter the threat of multidrug resistant bacterial infections. Possible scenarios of origin
and ongoing evolution of adpA orthologous group in Streptomyces conclude this monograph.
ABSTRACTING & INDEXING Regulatory Genes of AdpA Subfamily in Streptomyces: Function and
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proceedings volume is registered and indexed in the Crossref database and accessible on Amazon.

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