EAN: 9783527343379

METHODS AND PRINCIPLES IN MEDICINAL CHEMISTRY ...

Discusses how to fight Ebola  SARS Corona  and other known or emerging human viruses by
building on the successes in antiviral therapy of the past decades Written by leading medicinal
chemists and virologists from academia and industry  this book discusses the entire field of
antiviral drug discovery and development from a medicinal chemistry perspective  focusing on
antiviral drugs  targets  and viral disease mechanisms. It provides an outlook on emerging
pathogens such as Ebola  Zika  West Nile  Lassa  and includes a chapter on SARS Coronavirus-2
causing the present pandemic. 'New Drug Development for Known and Emerging Viruses' describes
the discovery and development process of antiviral agents for different species of viruses and
their targets based on the experiences from seven human viruses for which approved drugs are on
the market (HIV  HCV  Influenza  RSV  HBV  HCMV  and HSV). It covers the properties and
potential of currently approved antivirals  including combination drugs  and looks at novel
antiviral strategies against emerging viruses. * Covers the entire field of antiviral drug
discovery and development * Addresses the need for antiviral drugs to combat major health
threats such as Ebola  Zika  West Nile  and SARS Coronavirus-2 * Summarizes the successes of
the past years in developing ground-breaking medicines against 7 major human viruses  both from
the medicinal chemistry and the pharmacological angle * Discusses practical and strategic
challenges in the drug discovery and development process  including screening technologies 
latency  and toxicity issues 'New Drug Development for Known and Emerging Viruses' is an
important book for medicinal chemists  pharmaceutical chemists  virologists  and
epidemiologists  and will be of great interest to those in the pharmaceutical industry and
public health agencies.

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