EAN: 9783319524788

PROTEOMIC METHODS IN NEUROPSYCHIATRIC RESEARCH ...

Due to continuous technical developments and new insights into the high complexity of
neurological diseases  there is an increasing need for the application of proteomic
technologies which can yield potential biomarker readouts for improved clinical management as
well as for the development of new drugs by struggling pharmaceutical companies. This book
describes the step-by-step use of proteomic methods such as two-dimensional gel electrophoresis
multiplex immunoassay  liquid chromatography mass spectrometry (LC-MS) and selective reaction
monitoring MS  to increase our understanding of these diseases  with the ultimate aim of
improving patient care.The volume will be of high interest to clinical scientists  physicians
and pharmaceutical company scientists as it gives insights into the latest technologies
enabling the revolution of personalized medicine. It is of direct interest to both technical
and bench biomarker scientists as it gives step by step instructions on how to carry out each
of the protocols. It is also of interest to researchers as each technique will be presented in
the context of a specific neurological disorder  including Alzheimer's disease  multiple
sclerosis  autism spectrum disorders  schizophrenia  major depressive disorder and bipolar
disorder. Finally  it will also highlight the future research efforts in this field  which are
endeavoring to convert proteomic platforms to the form of hand held devices which can be used
in a point of care setting and return diagnostic results within the timeframe of a visit to the
general practitioner.

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